Southampton boss Ralph Hasenhuttl said it was a "risk" to play Danny Ings after he suffered a hamstring injury in the 1-0 defeat by Manchester City.
The England striker missed six weeks after knee surgery in November and hobbled off after 40 minutes.
Ings, who has scored six goals this season, was playing his fourth game in 13 days for the Saints.
"We had one day less to recover. It was a risk to play him. Hopefully he's not so bad," said boss Hasenhuttl.
The Austrian told BBC Match of the Day that the club will "have a look" at the extent of Ings' injury.
