Manchester United boss Ole Gunnar Solskjaer is not sure how many of his players will represent their countries this month.
Clubs are concerned about players having to come back to England and then quarantine for ten days after international matches.
Given the short turnaround between the break and the next set of league and European games, clubs may be without most of their top players for one or two games due to quarantine rules.
As such, some clubs may not allow players to go on international duty.
"We've not sat down and made a proper call on that one but it doesn't make sense if you lose your player for 10 days of isolation, of course it doesn't," Solskjaer told reporters after his team's 0-0 draw with Crystal Palace.
"We're the ones paying the players and from what I understand FIFA have given the rules that they don't have to be released.
"So I would think that's going to be a hard call to make to let them go and play in red list countries, yeah."
On Bruno specifically, Solskjaer added: "I want Bruno of course, ready against Brighton and hopefully that we are through in Europe and against Tottenham after that break, of course I do."
