Arsenal attackers Pierre-Emerick Aubameyang and Emile Smith Rowe are out of their clash with Sheffield United.
Mikel Arteta will be seeking a reaction from his side following their defeat to Liverpool in their last league outing.
But they will be without their striker, who is absent because of the flu.
Aubameyang's form has caused plenty of headlines with Arteta leaving the 31-year-old on the bench for Thursday's Europa League draw.
Smith Rowe meanwhile has been ruled out with an ankle problem, reports the Athletic.
Arsenal are meandering in 11th but a win will take them up to ninth, above Leeds and Aston Villa.
