Jamie Vardy picked up where he left off at the end of last season as his superb header for Leicester City meant Bruno Lage's Wolves tenure began with a 1-0 defeat.
The Foxes' number nine was the most lively player on the pitch and struck just before half-time courtesy of a timely run and clinical angled header from Ricardo Pereira's right-wing cross.
The 34-year-old, who netted 17 times last season including two on the final day against Tottenham, had earlier seen a finish from a tight angle ruled out for offside.
Afterwards, Leicester boss Brendan Rodgers said: "We had a really good pre-season and today we wanted to deliver. We played really well first half, some of the football we played was outstanding, and we didn't have too many problems. Second half we defended more and we could have made the game more comfortable, but to keep a clean sheet and play to that level was really pleasing.
"The fans gave us the energy, you see the connection the players have with the support, and they got us over the line."
On what Leicester can achieve this season, Rodgers added: "We're just out to do our very best. If you look at some other clubs and what they're spending, we're nowhere near that level. I just hope we can keep developing. If we can progress again this year I'll be happy and we'll see where that takes us."