Manchester United Under-23s were defeated 3-2 by Lincoln City in the EFL Trophy curtain raiser.
The young Reds were bested by Anthony Scully, who netted thrice at the LNER Stadium.
United did get goals back through Charlie McNeill and Bjorn Hardley.
However, youngster Hannibal Mejbri was sent off for two bookable offences.
United can still progress from their group, with Bradford City and Sunderland the other teams in that section.
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