Tottenham goalkeeper Hugo Lloris enjoyed a landmark game for victory over Manchester City.
Lloris equalled their all-time record for the most Premier League appearances by a single player, joining Darren Anderton on 299 games.
Nuno, meanwhile, becomes only the second Head Coach/manager to win his first Premier League game in charge of a club against the reigning champions.
Before this, there had been 20 different previous such occasions, with just one winning (Mike Phelan for Manchester United v Leicester in 2016/17).