England coach Southgate has confirmed there will be "a lot of changes" for their World Cup qualifier with Andorra.
This could mean playing time for the likes of goalkeeper Nick Pope, defender Tyrone Mings, midfielders Jude Bellingham and Jesse Lingard and forward Bukayo Saka.
Right-back Trent Alexander-Arnold, who missed Euro 2020 through injury, will be in the reckoning and there could be a first cap for Leeds striker Patrick Bamford.
"It's a special moment for him and for his family," said Southgate about Bamford, who scored 17 Premier League goals last season and has one so far this campaign.
"We want him to do what he does every week with his club. He has settled in really well with the group. He hasn't had a huge amount of time to be able to train with us yet but I think he's got a really clear picture of how we like to play.
"We just want him to go and enjoy his football. It's an opportunity and he shouldn't put any more pressure on himself than that. We know what he's capable of and we're looking forward to seeing him play."
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