Everton boss Rafa Benitez is concerned about the fitness of key trio Richarlison, Jordan Pickford and Seamus Coleman.
All three were absent from the 3-0 defeat to Aston Villa in the Premier League on Saturday.
Another who was unavailalbe for the game through injury was Jean-Philippe Gbamin.
Benitez told the club's website: "At the moment we think it would be two to three weeks minimum [for Richarlison, Pickford and Coleman] and after we will see.
"[Gbamin] was a little bit tight in his quadriceps so as a precaution we decided to keep him out of the squad."
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