The win now puts the Blues ahead of Juve on goal difference to sit atop of Group H.
Thomas Tuchel's side dominated at Stamford Bridge from start to finish, breaking the deadlock through Trevor Chalobah's instinctive short-range finish after 25 minutes.
Reece James continued his fine form with a thunderous struck to make it 2-0 ten minutes after half-time.
It took only another three minutes for academy graduate Callum Hudson-Odoi to put the game out of sight with a simple finish for Chelsea's third.
Timo Werner capped off a wonderful night for the west London club by converting a superb team goal deep into stoppage time.
Max Allegri's Juve had conceded just four goals in four Champions League games before arriving in London on Tuesday.
The Italian giants will now have regain some confidence ahead of Saturday's clash with Atalanta.
Chelsea will be buzzing after an utterly dominant performance as they now look towards a blockbuster meeting with Manchester United on Sunday.
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