Tottenham boss Antonio Conte admitted frustration after their 1-1 draw with Southampton.
Spurs fell behind at St Mary's when James Ward-Prowse cut across a bouncing ball to volley a swerving shot past Hugo Lloris for a superb opener.
But the game turned when Mohammed Salisu fouled Heung-min Son in the box to earn a second booking in 12 first-half minutes and allow Harry Kane to level from the penalty spot.
Conte said, "We have to be disappointed because you have to exploit the situation against 10 men.
"To play after 44 hours is not easy because you need to recover from the last game. Maybe the fatigue caused bad decisions especially when we arrived in their box. It's not easy to take a good result in this stadium. In the end we could do better.
"I don't want to comment on this decision or situation [to disallow a goal for a foul on the keeper]. There is the referee and the VAR. We have to accept the decision.
"He [Harry Kane] played a good game. He could have scored twice. His performance was good. At the end he played a bit of fatigue like the whole team. It's OK."
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