Atletico Madrid captain Koke is struggling to make their Champions League round 16 first-leg clash with Manchester United.
Reports in Spain claim the key midfielder picked up an injury in the 3-0 weekend win over Osasuna and missed training with his team-mates on Monday.
Atletico will check Koke's fitness but if he fails to recover it would be a big blow for Diego Simeone's side.
And the Argentine boss could be facing a selection crisis ahead of Wednesday's first leg clash at the Wanda Metropolitano with Matheus Cunha and Daniel Wass also sidelined.
Thomas Lemar and Benjamin Lecomte are doubts too after missing training over the weekend.
While Yannick Carrasco and Felipe are both suspended.
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