Manchester United will be without Alex Telles and Fred for the trip to Burnley on Tuesday.
The Brazilian pair have tested positive for COVID-19.
"Yeah we have two players missing," manager Ralf Rangnick told MUTV.
"Alex Telles already missed the cup game because he tested COVID positive last week and, unfortunately, the same thing happened today with Fred.
"That's why he will be missing from tomorrow's game and possibly even the game against Southampton."
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