The Argentina international is currently starring on-loan with Villarreal this season.
Estadio Deportivo says Lo Celso is now ready to leave Spurs permanently over the summer.
He would be open to signing permanently with Villarreal, though his mooted €50m valuation could prove too rich. Lo Celso has a deal to 2025.
Sevilla chief Monchi is also monitoring developments closely.
Need a VPN? Or seeking to switch? Then support Tribal Football by clicking here to sign up with our official partners NordVPN. Not only will you receive the best VPN experience, but also great discounts by signing up via Tribal Football. Thanks for your support!