Arsenal have lost defensive pair William Saliba and Oleksandr Zinchenko for the remainder of the season.
A point behind Premier League leaders Manchester City, Arsenal must make do without both defenders due to injury, says the Athletic.
Saliba has finally admitted defeat in his attempts to recover from a back injury.
Meanwhile, Zinchenko was forced off in Arsenal's 2-0 win at Newcastle last Sunday with a strain and needs time to recover.
The Gunners host Brighton this Sunday.