Arsenal medical chiefs do not expect William Saliba to be back for their trip to Manchester City.
Saliba is recovering from a back injury suffered against Sporting CP in the Europa League.
With a trip to City in April 26 there was hope Saliba would be fit in time.
But the London Evening Standard says Arsenal will have to face City without the Frenchman as the club's medical staff say he won't be fit.
City closed the gap on Arsenal to just three points on the weekend with their win over Leicester City as the Gunners drew at West Ham.
Pep Guardiola's side have a game in hand on the North London side, but will not play a Premier League match until the clash in Manchester.