Christina Applegate reveals possible new diagnoses after MS debacle

Health & Fitness
4 Nov 2026 • 7:03 PM MYT
The Independent
The Independent

The world’s most free-thinking newspaper

Christina Applegate reveals possible new diagnoses after MS debacle

  • Christina Applegate has shared a health update after recently revealing she was misdiagnosed with multiple sclerosis.
  • The 54-year-old is currently undergoing testing for alternative conditions that mimic MS symptoms, including lupus, Lyme disease, and rheumatoid arthritis.
  • Applegate stated that she remains in severe pain and that her illness remains a mystery, leaving her feeling like she is back at square one.
  • Speaking on her MeSsy podcast, she admitted to struggling with her identity following the misdiagnosis and appealed to listeners for advice.
  • Applegate previously retired from acting in 2022 following her initial 2021 diagnosis and the conclusion of her Netflix series Dead to Me.

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