Liverpool will face Sparta Prague in the Europa League last-16 while Brighton play Roma in what will be a historic knockout tie for the Seagulls.
Rangers were drawn against Benfica as West Ham were paired with German side Freiburg, who David Moyes’s side defeated twice in the group stages.
Brighton are playing their first ever European campaign under Roberto De Zerbi and the Italian will take his team to Rome before hosting the Serie A side on the south coast.
Liverpool received a favourable draw against Sparta Prague while Rangers will face Portuguese giants Benfica in a glamour European tie.
West Ham received a familiar draw against Freiburg, who they have already played this season - winning in London and in Germany.
Xabi Alonso’s Bayer Leverkusen play Qarabag, Sporting Lisbon face Atalanta, Villareal play Marseille and AC Milan take on Slavia Prague.
The last-16 ties will take place on 7 March and 14 March, with the seeded teams - in this case all four British sides - at home for the second leg.
Follow the last 16 draw and reaction as Jurgen Klopp eyes glory in Dublin to end his reign at Anfield:
