Ivan Toney scored one and assisted another as Brentford boosted their European hopes and heaped further misery on bottom club Southampton with a win at St Mary's.
Toney tapped in Christian Norgaard's flick-on after a Bryan Mbeumo corner in the 32nd minute.
And in second-half injury-time his header sent through Yoane Wissa who calmly doubled the visitors' lead.
Victory saw the Bees move up to eighth in the Premier League table.
Southampton stay 20th, two points off safety having played one game more than most of their relegation rivals.
Bees manager Thomas Frank later said, "I thought [we had] great bounce-back mentality the players and team worked very hard. We played with high intensity and created a lot of chances. We got 1-0 up and I was very pleased with that.
"In every season there are games where you need to dig in, get the job done and get the three points and we did that today.
"[Set-pieces] are something we work very hard on so [our first goal] that is very pleasing.
"[Southampton] came with everything, they are playing for their lives and I have to say they did very well. Between the boxes they were actually better than us but in the boxes that's where you decide the game."
