Manchester rivals City and United will meet in the group stages of the Women's Continental League Cup competition.
Holders City were drawn to face United in Group C, alongside Birmingham City, Everton and second-tier Leicester City.
The top two clubs from each group will progress to January's quarter-finals.
Group-stage matches will be played on the weekends of 21-22 September, 19-20 October, 2-3 and 20-21 November and 11-12 December.
The quarter-finals and semi-finals will follow in January, when the competition enters a knockout phase, before a leap-year final on 29 February.
The 23 teams in the Women's Super League and the Championship take part, and they have been divided regionally into two northern groups and two southern groups.
