Labour is facing a rebellion against its welfare Bill as opponents launch an amendment to stop the cuts from progressing through Parliament.
A reasoned amendment due to be published on Tuesday will seek to halt the Bill.
Commons Speaker Sir Lindsay Hoyle would need to select the amendment when MPs debate the legislation at its second reading.
But it could pose a major challenge to the Government’s plans.
Dozens of MPs, including eleven select committee chairs, are understood to have backed it.
It comes after Work and Pensions Secretary Liz Kendall sought to talk up the changes and persuade backbench MPs at a meeting of the Parliamentary Labour Party (PLP).
Under the proposals, ministers will limit eligibility for the personal independence payment (Pip), the main disability payment in England, and limit the sickness-related element of universal credit (UC).
The amendment acknowledges the need to reform the social security system but calls to reject the Bill because of a lack of consultation with disabled people and their carers.
It also makes the case that arrangements are not in place to help those affected by the changes, noting that most additional employment support funding will not be in place until the end of the decade.
And it points to the fact that an analysis of the impact of the reforms on employment from the Office for Budget Responsibility will not be published until the autumn.
The Government has faced a growing backlash to its planned reforms, with Labour MP Vicky Foxcroft resigning as a Government whip because of her concerns over the package.
MPs continued to voice their concerns in the Commons on Monday.
Next week's Universal Credit and PIP Bill will impose poverty on disabled people.
— Andy McDonald MP for Middlesbrough & Thornaby East (@AndyMcDonaldMP) June 23, 2025
It is unacceptable the government are not publishing key information on the scale of that impact. pic.twitter.com/Jz0NYzQZxP
Andy McDonald, who represents Middlesbrough and Thornaby East, said he and his colleagues were being asked to vote on imposing “appalling poverty”.
Ministers have previously said the reforms could save up to £5 billion a year.
The Work and Pensions Secretary told the PLP that the plans are “rooted in fairness”.
Ms Kendall said: “The path to a fairer society – one where everyone thrives, where people who can work get the support they need, and where we protect those who cannot – that is the path we seek to build with our reforms.
“Our plans are rooted in fairness – for those who need support and for taxpayers.”
She argued they are about ensuring the survival of the welfare state so there is always a safety net for those in need of it.
Ms Kendall added: “But above all they are about our belief that everyone can fulfil their potential and live their hopes and dreams when, collectively, we provide them with real opportunities and support.
“This is the better future we seek to build for our constituents and our country.”
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