Liverpool boss Jurgen Klopp has Champions League concerns for Darwin Nunez.
Liverpool take on holders Real in a repeat of last May's final, with the round 16 first leg at Anfield on Tuesday night.
However, Klopp may be forced to take on the European champions without Nunez after he was withdrawn with a painful shoulder injury. The Uruguayan suffered the issue after jumping up for a header and falling awkwardly.
"The most negative thing was that Darwin [Nunez] had to go off. We have to see how serious that is hopefully not too much," Klopp explained.
He added: He had to go off with that issue and we need further assessment. I don't know [the extent] in this moment. In this moment it is painful. Hopefully it is just painful and nothing more. We have to see how serious that is hopefully not too much."