Liverpool management fear Andrew Robertson will require surgery on his dislocated shoulder.
The Reds are waiting on results from medical tests after Robertson returned from Scotland duty this week.
Robertson suffered a dislocated shoulder in the Euro qualifier against Spain after a collision with goalkeeper Unai Simon.
The Liverpool Echo says are poised to discover whether the 29-year-old will require an operation to repair the damage, which would rule him out for a significantly lengthy period.
Liverpool will need to count on Kostas Tsimikas as cover for the Scot, with the Greece left-back having been used in Cup and European competition so far this season.