Manchester City midfielder Rodri is ready to face Scotland pair Scott McTominay and John McGinn.
The 26-year-old has directly come up against Manchester United counterpart McTominay in derbies over the past few seasons and knows the Scot will be on a high after his two late goals in Saturday's 3-0 win over Cyprus.
While Spain saw off Norway by the same scoreline to make a successful start under new national coach Luis de la Fuente, Rodri is adamant they must now deliver to take command of Group A in Glasgow.
Aston Villa's McGinn, scorer of Scotland's opener at the weekend, is another of his midfield sparring partners from the club game.
"I know them very well, of course," said Rodri. "They are talented players with a lot of physicality to go box to box.
"I think they are of massive importance to the national team and, of course, they have experience of playing big games in the Premier League against us, for example.
"With Scott, it's a big rivalry, of course, in the Manchester derby.
"They are good players, as we have also. We don't focus too much on individual players, more on the things they do collectively.
"We also try and focus on ourselves to produce a good performance against one of the best teams in the group.
"This is going to be an important game. If we can win, we'll have taken six points from the two best teams in the group Scotland and Norway so it's going to be a very tough game.