Manchester United boss Erik ten Hag admits they missed Christian Eriksen against Newcastle.
The Dane was forced out of Sunday's 0-0 draw due to illness.
Ten Hag said, "We miss him when he is not available, but we have a squad and 11 other players on the pitch. Then we have to construct another team and we can bring players from the bench who are all good.
"I cannot say whether he is ready against Spurs. I know you are from Denmark and want to know and I want to say that he has played fantastic for us. In our team, he really contributes to what we are at the moment.
"I don't know if he will be ready for Wednesday, but I hope so."