New finding may explain why women face higher dementia risk

Health & Fitness
27 Jan 2026 • 9:44 AM MYT
The Independent
The Independent

The world’s most free-thinking newspaper

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  • New research from the University of Cambridge, involving 124,780 women, has linked menopause to a reduction in brain grey matter, which is crucial for mental functions, memory and emotions.
  • This finding could help explain why women face a higher risk of dementia compared to men, as the affected brain regions are often impacted by Alzheimer's disease.
  • The study revealed that post-menopausal women not undergoing hormone replacement therapy (HRT) exhibited slower reaction times compared to pre-menopausal women or those using HRT, suggesting HRT may slow this ageing process.
  • Beyond physiological changes, menopause was also found to exacerbate issues such as anxiety, depression and sleep disturbances, with post-menopausal women reporting more tiredness.
  • Experts emphasise the importance of a healthy lifestyle during menopause to mitigate some of its effects, and highlight that these symptoms may have a biological basis rather than being dismissed as ageing or stress.

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