New weight loss pill was more effective than semaglutide in trial

Health & Fitness
26 Feb 2026 • 8:01 PM MYT
The Independent
The Independent

The world’s most free-thinking newspaper

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  • A new once-a-day weight loss pill, orforglipron, has been hailed as an “important advancement” in type 2 diabetes care following a new study.
  • The study compared orforglipron against oral semaglutide, an existing tablet version of a GLP-1 receptor agonist, finding it superior for blood sugar reduction and weight loss.
  • Patients taking orforglipron lost between six and eight per cent of their body weight, compared to four to five per cent for those on semaglutide.
  • A key advantage of orforglipron is that it can be taken without restrictions on food or water intake, unlike oral semaglutide, which requires an empty stomach.
  • While more patients on orforglipron reported gastrointestinal side effects, experts from Diabetes UK welcomed the findings, highlighting the importance of diverse treatment options.

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