Newcastle chief Darren Eales concedes they must sell a big name to ease Financial Fair Play pressure.
Bruno Guimaraes and Sven Botman have been linked with moves away. Eales admits the Premier League's Profit and Sustainability rules forces clubs "to trade".
Eales said: "It's difficult to hypothesise but, if we're offered 1billion for one of those players, then no-one could argue against that making sense.
"If we're going to get to where we want to get to, at times it is necessary to trade your players.
"It is counter-intuitive and part of the inherent system of PSR that there is an incentive to trade your players, if you want to re-invest."