- A new study suggests an individual's genetic makeup can influence the effectiveness of weight-loss injections and the likelihood of experiencing side effects.
- Researchers identified specific gene variants that predict both the degree of weight loss achieved and the occurrence of adverse reactions like nausea and vomiting from GLP-1 receptor agonists.
- The study, published in Nature, analysed data from nearly 28,000 people using drugs such as semaglutide (Wegovy) and tirzepatide (Mounjaro).
- While genetic differences may partially account for variations in weight loss, experts note that the effects are modest compared to non-genetic factors like gender, age, and treatment type.
- The findings offer a pathway towards precision medicine but are not yet sufficient to guide routine clinical decisions, as genetics is only one part of a complex picture.
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