Selma Blair has shared a health update following her Multiple Sclerosis diagnosis.
The 53-year-old Legally Blonde star was diagnosed with the autoimmune disease, which affects the brain and spinal cord, in 2018. Symptoms can include numbness or tingling, dizziness, loss of coordination or difficulty walking, according to the Mayo Clinic.
Blair made an appearance on Tuesday’s episode of Today and shared that, despite feeling “tired a lot,” she is doing “really well.”
“That's just the truth of it. So I don’t want any of the people with chronic illness to feel like, ‘How does she do that?’ I’m like, ‘Oh no, no, that’s makeup and happiness. There’s fatigue,’” she shared. “But I am, really, really well. I am relapse-free. I’m happy.”
An MS relapse is described as the occurrence of new symptoms or the worsening of old ones for at least 24 hours when it’s been 30 days since the last relapse, according to the National Multiple Sclerosis Society.
During her appearance on Today, Blair noted that she’s “ready” to get back to work next month, when she’ll be filming Ethan Almighty - Ethan's Law. The film is based on the viral true story of Jeff Callaway, who adopted a severely neglected dog, Ethan, after he was found in a Kentucky Humane Society parking lot.
In the new movie, Blair plays Claire Patterson, who is struggling with questions of faith and a personal loss, but has a powerful change in perspective when she meets Ethan.
Outside of her acting career, she’s partnered with Mersea to launch a limited-edition line of pajamas, Sea La Vie, which was inspired by her experience with MS and desire for comfort.
“There are personal, charming touches, I’d say,” she said while describing the pajamas she was wearing on the show. “[Mersea] was so supportive, wonderful and loving towards me when I was going through some challenges. So when I got better, I called them, and I’m like, ‘Girls, will you do a collab with me?’”
The Cruel Intentions star has previously opened up about being in a good place amid her MS. She told People in April 2025 that she was “doing amazingly well” and “relapse-free.”
“I've been feeling great for about a year,” she told the publication at the time. “But I am finally well enough to really, genuinely ... I always try and feel my best, but now that I actually have stamina and energy and getting out and going out isn't so scary.”
In 2023, Blair told British Vogue that her doctor initially advised her to keep her diagnosis a secret.
“The advice was to keep it to myself. That work ‘wouldn’t have to know.’ People didn’t feel safe sharing that stuff,” she told the publication.
Blair detailed some of the physical challenges she faced throughout her childhood, decades before being diagnosed with MS. At the age of seven, she told Vogue, she lost use of her right eye, left leg, and her bladder.
While she didn’t realize it then, the symptoms she had were a result of juvenile MS. Her doctor at the time didn’t take her health struggles seriously, and her condition as a child went undiagnosed.
“If you’re a boy with those symptoms, you get an MRI,” she said. “If you’re a girl, you’re called ‘crazy.’”
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