Study reveals how much weight returns after stopping weight loss jabs

Health & Fitness
5 Mar 2026 • 9:38 AM MYT
The Independent
The Independent

The world’s most free-thinking newspaper

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  • Individuals using GLP-1 obesity medications such as Mounjaro or Wegovy are likely to regain almost two-thirds of the weight they lost within a year of stopping the drugs.
  • A study by the University of Cambridge, involving over 3,200 people, found that patients regained 60 per cent of lost weight after 52 weeks off the jabs.
  • While most weight is regained, researchers suggest approximately 25 per cent of the initial weight loss may be sustained in the long term.
  • Experts caution that if the regained weight is predominantly fat, individuals could be “worse off than before” they started treatment, potentially impacting their health.
  • Researchers are calling for future trials to investigate the composition of weight loss and for improved prescribing guidelines, as current advice is inconsistent regarding post-treatment weight regain.

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