Fabio Paratici has formally resigned from Tottenham as football director.
The former Juventus chief lost his appeal yesterday against a 30-month worldwide FIFA ban.
Paratici has been suspended from football for his role in Juventus' capital gains scandal, which saw their board resign before Christmas.
A Spurs statement said: "Fifa ruled to extend the ban worldwide and, whilst there continues to be a dispute as to the scope and extent of the ban, the current worldwide ban prevents Fabio from fulfilling his duties as our managing director of football.
"Fabio has consequently taken the decision to resign from his position at the club with immediate effect to focus on his legal position in respect of the FIGC (Italian Football Federation) and Fifa rulings."
Spurs chairman Daniel Levy also said: "This has been a stressful time for Fabio and his family.
"We wanted to ensure that we allowed for due process to be followed. Fabio is a man who lives and breathes football - we wish him well.
"As outlined in our year-end results, we started several months ago to restructure our football operations and last week announced the appointment of Scott Munn as chief football officer to head up all the departments.
"We shall continue to strengthen our football functions over the coming months."
