Teenage striker Mason Greenwood will start Manchester United's Europa League group game against Astana at Old Trafford on Thursday, reports BBC Sport.
The 17-year-old has already made four substitute appearances in the Premier League this season.
England under-21 defender Axel Tuanzebe will also start, alongside reserve goalkeeper Sergio Romero and Brazilian midfielder Fred.
"He's still very young. I remember the kid who just wanted to play with his mates in the under-18s," said Solskjaer. "Now he's knocking on the door and his appetite for football must be growing.
"I just don't want to put too much pressure on him. Mason's one of the best finishers I've seen and I've played with a few decent ones.
"When you're 17, 18, 19 years old, the next game is always the most important one. It doesn't matter how many you scored last week.
"There will be 11 Astana players living the dream - it is one of the biggest games of their careers - but I want it to be a memorable one for our players as well."