Wolves are waiting for scan results to see the extent of Diego Costa's injury suffered in victory over Tottenham.
The striker landed awkwardly and damaged his knee, before needing to be stretchered off.
Wolves will hope the prognosis is similar to Cunha, who was also stretchered off at Fulham but avoided a serious injury and only missed one game.
When asked about Costa, Lopetegui said: We are going to check him tomorrow. He showed pain in his knee. We have to wait."
Daniel Podence was also left out of the squad altogether, as he seemingly falls further out of favour with the head coach.
Lopetegui confirmed the decision was tactical and not down to injury. The winger has also not started for Wolves since January 14, when he scored in a win over West Ham.