James Ward-Prowse scored a dramatic 96th-minute penalty soon after Allan Saint-Maximin appeared to grab an injury-time winner for Newcastle as Southampton earned a point in a thrilling encounter at St James' Park.
The hosts had looked set to pick up their first win of the season after Saint-Maximin struck in the 90th minute, firing in from a loose ball after Alex McCarthy had initially denied Ryan Fraser's effort.
But Southampton were awarded a spot-kick by VAR soon after when Adam Armstrong was fouled by Jamaal Lascelles inside the box, and Ward-Prowse stepped up to confidently slam home the penalty.
It was a deserved point for the Saints who had dominated much of the game. They spurned several chances to take the lead in the first half before Callum Wilson headed Newcastle in front against the run of play after the restart.
Mohamed Elyounoussi, who scored a hat-trick in an 8-0 win against Newport County in the League Cup in midweek, bundled in an equaliser late on after his initial effort was kept out by Freddie Woodman.
But then came the drama of injury time as Newcastle fans celebrated wildly what looked to be a winner from Saint-Maximin before Ward-Prowse's penalty ended a run of seven straight defeats on the road in the Premier League for Southampton.
Afterwards, Wilson said: "It's crazy. Football is harsh at times.
"We still haven't learnt our lesson. It's obviously frustrating - everyone is frustrated but it's the way it's going at the minute. Sometimes it happens, you've got to find a way to get a result.
"Things aren't going our way for the minute but we have to dig in over the international break.
"You're always vulnerable when you have just scored but as professionals they shouldn't be nicking it late on like that.
"We had enough chances in the game. We are conceding too many goals at the minute. We need to work harder to make sure that stops because it's disappointing when you score what should be a last-minute winner and then it gets taken away.
"[Jamaal] Lascelles has tried to stop a last-minute goal. We're all behind him and we stand together as a team.
"It's nice to wear the number nine shirt and it's nice to score at the home end. I'm happy with the positives to get on the scoresheet but at the end of the day, we didn't really get the points."
Need a VPN? Or seeking to switch? Then support Tribal Football by clicking here to sign up with our official partners NordVPN. Not only will you receive the best VPN experience, but also great discounts by signing up via Tribal Football. Thanks for your support!