In victory over Denmark, Scotland captain Andrew Robertson was substituted off in the 79th minute after falling to the turf.
The Reds left back underwent a scan on Tuesday to determine the severity of the problem and, while Liverpool do not think the injury is serious, they are not prepared to take any chances, says The Times.
Instead Tsimikas will return to deputising duty for Jurgen Klopp's side.
The Greece international has proven to be an able understudy this season, providing two assists in eight games across all competitions.
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