Toney has missed Brentford's last two matches with a calf injury.
"We hope he will be (available)," boss Frank said.
"He'll be assessed during the week and we'll do everything we can to get him available.
"It's not like we can say he will 100% be fit, but it's something we are hoping for and think that could be realistic but it depends on how he is progressing during this week.
"Of course we would love to have our top scorer out there on the pitch but I think Bryan (Mbeumo) and (Yoann) Wissa are good strikers and good players who can score goals."
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