Roberto de Zerbi has hinted at differences over Brighton's transfer plans led to his departure.
The Italian will leave as manager after Sunday's season finale against Manchester United.
De Zerbi said: "We have agreed to end my time at Brighton so that the club and I can continue to work in the way that suits each of us best, following our own ideas and visions, as well as our work and human values.
"Leaving now provides me with time to take a break before deciding on my future plans.
"I am very sad to be leaving Brighton, but I am very proud of what my players and staff have achieved with the support of everyone at the club and our amazing fans in the past two historical seasons."