The strikes damaged high-rise buildings, private homes, a school, a supermarket, and cars, according to the State Emergency Service, which evacuated over 200 residents.
Regional governor Oleh Kiper said on social media that multiple fires broke out across the city following the strike.
Attacks were also reported in Kharkiv and Sumy, where a strike caused a blaze but no injuries.
The escalation comes as Ukraine and the US signed a deal to share future profits from Ukrainian minerals and rare earths.
