Miguel Almiron scored twice and Callum Wilson netted on his return from injury as Newcastle United hit four past 10-man Fulham at Craven Cottage to move up to sixth in the Premier League.
Fulham's day started poorly when Nathaniel Chalobah was shown a straight red card for a high challenge on Sean Longstaff in the eighth minute.
Three minutes later Wilson turned in Joe Willock's header, before Almiron effectively killed off the game in the 33rd minute with a superb looping volley.
Longstaff added a third for the visitors just before the break, striking home a rebound after Fulham goalkeeper Bernd Leno tipped Sven Botman's header on to the post.
And in the second half Almiron tapped in his second, pouncing on a Willock pass across goal.
Fulham scored a late consolation, with Bobby Decordova-Reid heading home Neeskens Kebano's cross.
Afterwards, Toon boss Eddie Howe said: "It has been a long time coming. We have had a long wait for the second win of the season.
"Right from the start we had a good feeling, with good energy, and created chances early on. Obviously the red card made it easier but I am very pleased with the players' response. Their attitude - we wanted more, we weren't happy with what we had, always trying to score.
"It's been a very difficult two weeks, obviously we have had the international break with players going away, but we have also had a bit of illness in the camp, so it's been a mixed two weeks but it didn't show in our performance."