Luton boss Rob Edwards has confirmed several players could be departing in the coming weeks.
The likes of Luke Freeman, Admiral Muskwe, Dion Pereira and Glen Rea are all surplus to requirements.
After winning promotion to the Premier League through the playoffs, the Hatters must now try to compete at the top level for the first time in decades.
Asked if many players could leave his bloated squad, Edwards told reporters: Potentially yes.
"It's difficult these times when you've got to shape a squad, you've got to name a 25-man squad and the two of them have been fantastic, really, really professional.
"I can't speak highly enough of them, but it's just unfortunate.
"I can't play everyone and when we want to try and bring some people in, there are some casualties.
"But that's something that we're trying to help them with and make sure they do get the right move that they deserve as well."