- Serena Williams made her return to Arthur Ashe Stadium, partnering Carlos Alcaraz in the US Open mixed doubles event before being eliminated in the quarter-finals.
- Williams and Alcaraz defeated Erin Routliffe and Lloyd Glasspool in the first round before falling to fourth seeds Belinda Bencic and Flavio Cobolli.
- Top seeds Novak Djokovic and Aryna Sabalenka suffered an early exit, losing their opening match to Katerina Siniakova and Henry Patten.
- Gael Monfils and Elina Svitolina reached the semi-finals by overcoming Siniakova and Patten in a deciding tie-break.
- All doubles specialists were eliminated prior to the semi-finals under the tournament's revamped format designed to showcase singles stars.
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