New Manchester United boss Erik ten Hag will face Liverpool at Old Trafford inside the third week of the new season.
The home encounter with Jurgen Klopp comes after they host Brighton and a visit to Brentford in the second week of the campaign.
United go up against all of the 'big six' in Ten Hag's opening 13 matches, putting further pressure on the club's hierarchy to deliver in the summer transfer window.
He will take his side to champions Manchester City in the first derby of the season on October 1, which immediately comes after United welcome Leeds to Old Trafford.
An awkward October also includes a home clash with Tottenham and a visit to Stamford Bridge to take on Thomas Tuchel's Chelsea.
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