Ivan Toney passed the 50-goal mark for Brentford in style with a superb hat-trick to condemn Leeds to a second successive Premier League away defeat.
Toney opened the scoring with a penalty, awarded after a foul by Luis Sinisterra and a long VAR intervention, then doubled the hosts' lead with a superb free-kick, and chipped in his third after the break.
Sinisterra had made it 2-1 just before half-time, but then came Toney's hat-trick goal, and a red card for Leeds boss Jesse Marsch, sent off after urging referee Robert Jones to use the monitor to review a challenge by Aaron Hickey on Crysencio Summerville.
Marc Roca gave the visitors hope again, but Bryan Mbeumo put Brentford 4-2 up before Yoane Wissa added a late fifth.
The win lifted Brentford to seventh in the table, while Leeds slipped to ninth and are still seeking their first victory on the road this season.
