Top seeds Arsenal will play Bayer Leverkusen in the Champions League round of 16 while Manchester City will take on record winners Real Madrid.
The draw, which took place at UEFA’s headquarters in Nyon on Friday morning, saw Liverpool drawn against Galatasaray, with Chelsea to face holders Paris St Germain.
Tottenham will play Atletico Madrid and Newcastle have been drawn to play Barcelona as six Premier League clubs bid to reach the quarter-finals.
The seeded teams, who finished in the top eight of the league phase, were all drawn against one of the eight play-off winners and will have the advantage of playing the second legs at home.
The first legs will be played on March 10-11, with the second legs scheduled for March 17-18.
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