Sevilla coach Julen Lopetegui admits defender Jules Kounde may be on the move.
Kounde is a serious target for Barcelona, with Marcao having arrived from Galatasaray as a replacement.
“One very important player, Diego Carlos, left, and maybe the other starting centre back (Jules Kounde) will too," said Lopetegui.
“We don't know what will happen.
"They are difficult to replace and we will have to help Marcao (new signing from Galatasaray) adapt quickly to what's demanded of him."
Sevilla have been seeking over €50m to sell Kounde.
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