Ukrainian strikes targeted the Russian hinterland overnight, with 326 drones intercepted across the country, the Russian Defence Ministry said on Wednesday.
While it is not possible to independently verify the figures, it suggests a large-scale Ukrainian attack.
A refinery in Samara on the Volga river in western Russia was among the targets hit, according to Russian Telegram channels.
Two infrastructure objects were damaged in the Vladimir region east of Moscow, according to local authorities. Reports on Telegram said the sites were also linked to the country's oil industry.
Three people were injured by a missile strike in the city of Cheboksary, which is also located on the Volga river, some 600 kilometres east of Moscow, authorities said.
Cheboksary is home to an arms manufacturing facility.
A drone alert was also triggered in the Siberian city of Omsk, which lies 2,800 kilometres from Kiev and is home to Russia’s largest oil refinery. However, no reports of an actual attack have emerged so far.
Meanwhile, a drone struck a history museum in the city of Sevastopol on the Black Sea peninsula of Crimea, which Russia annexed illegally in 2014.
The head of the occupation administration, Mikhail Razvozhayev, described the incident on Telegram as a targeted attack on a cultural institution.
This would, however, be an unusual target for the Ukrainian armed forces, which have been trying to disrupt Russia's oil and military industry in a bid to end the war.
